Emergence of high-level colistin resistance mediated by multiple determinants, including mcr-1.1, mcr-8.2 and crrB mutations, combined with tigecycline resistance in an ST656 Klebsiella pneumoniae

Colistin and tigecycline are usually regarded as the last resort for multidrug-resistant Klebsiella pneumoniae infection treatment. Emergence of colistin and tigecycline resistance poses a global healthcare challenge and is associated with high mortality due to limited therapeutic options. Here, we...

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Autores principales:	Yanfei Wang, Junxin Zhou, Haiyang Liu, Qian Wang, Ping Zhang, Jingyi Zhu, Dongdong Zhao, Xueqing Wu, Yunsong Yu, Yan Jiang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2023-01-01
Colección:	Frontiers in Cellular and Infection Microbiology
Materias:	colistin mcr tigecycline tmexCD1-toprJ1 co-integration
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fcimb.2023.1122532/full
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