CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine
Abstract Background To investigate specific brain regions and neural circuits that are responsible for migraine chronification. Methods We established a mouse model of chronic migraine with intermittent injections of clinically-relevant dose of nitroglycerin (0.1 mg/kg for 9 days) and validated the...
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| Principais autores: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BMC
2022-12-01
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| Serija: | The Journal of Headache and Pain |
| Teme: | |
| Online dostop: | https://doi.org/10.1186/s10194-022-01531-8 |
| Oznake: |
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