Inter-Antibody Variability in the Clinical Pharmacokinetics of Monoclonal Antibodies Characterized Using Population Physiologically Based Pharmacokinetic Modeling

The objective of this work was to develop a population physiologically based pharmacokinetic (popPBPK) model to characterize the variability in the clinical PK of monoclonal antibodies (mAbs) following intravenous (IV) and subcutaneous (SC) administration. An extensive literature search was conducte...

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Auteurs principaux:	Mokshada Kumar, Sravani Lanke, Alka Yadav, Mfonabasi Ette, Donald E. Mager, Dhaval K. Shah
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2024-07-01
Collection:	Antibodies
Sujets:	antibody clinical pharmacology pharmacokinetics PBPK model
Accès en ligne:	https://www.mdpi.com/2073-4468/13/3/54
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