Inter-Antibody Variability in the Clinical Pharmacokinetics of Monoclonal Antibodies Characterized Using Population Physiologically Based Pharmacokinetic Modeling

The objective of this work was to develop a population physiologically based pharmacokinetic (popPBPK) model to characterize the variability in the clinical PK of monoclonal antibodies (mAbs) following intravenous (IV) and subcutaneous (SC) administration. An extensive literature search was conducte...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Mokshada Kumar, Sravani Lanke, Alka Yadav, Mfonabasi Ette, Donald E. Mager, Dhaval K. Shah
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	MDPI AG 2024-07-01
סדרה:	Antibodies
נושאים:	antibody clinical pharmacology pharmacokinetics PBPK model
גישה מקוונת:	https://www.mdpi.com/2073-4468/13/3/54
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