Age and onset timing of Raynaud’s phenomenon and first non-Raynaud symptom as prognostic factors in systemic sclerosis: a retrospective analysis from the Italian national multicenter Systemic Sclerosis Progression INvestiGation registry of the Italian Society for Rheumatology (SPRING-SIR)

Background: The sequence and temporal relationship between Raynaud’s phenomenon (RP) and the first non-Raynaud’s sign/symptom (NRP) in systemic sclerosis (SSc) have been partially investigated. Objectives: To evaluate whether the mode and ages of clinical onset are associated with disease endotype a...

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Autors principals:	Silvia Peretti, Cosimo Bruni, Francesco Bonomi, Rossella De Angelis, Gianluigi Bajocchi, Dilia Giuggioli, Martina Orlandi, Giovanni Zanframundo, Roberta Foti, Elisa Visalli, Giovanna Cuomo, Alarico Ariani, Edoardo Rosato, Gemma Lepri, Francesco Girelli, Valeria Riccieri, Elisabetta Zanatta, Silvia Laura Bosello, Ilaria Cavazzana, Francesca Ingegnoli, Maria De Santis, Fabio Cacciapaglia, Giuseppe Murdaca, Giuseppina Abignano, Giorgio Pettiti, Alessandra Della Rossa, Maurizio Caminiti, Annamaria Iuliano, Giovanni Ciano, Lorenzo Beretta, Gianluca Bagnato, Ennio Lubrano, Ilenia De Andres, Luca Idolazzi, Marta Saracco, Cecilia Agnes, Corrado Campochiaro, Giacomo De Luca, Edoardo Cipolletta, Marco Fornaro, Federica Lumetti, Amelia Spinella, Luca Magnani, Veronica Codullo, Carlo Iandoli, Antonietta Gigante, Greta Pellegrino, Erika Pigatto, Maria Grazia Lazzaroni, Enrico De Lorenzis, Gianna Angela Mennillo, Marco Di Battista, Giuseppa Pagano Mariano, Federica Furini, Licia Vultaggio, Simone Parisi, Clara Lisa Peroni, Gerolamo Bianchi, Enrico Fusaro, Gian Domenico Sebastiani, Marcello Govoni, Salvatore D’Angelo, Franco Cozzi, Franco Franceschini, Serena Guiducci, Lorenzo Dagna, Andrea Doria, Carlo Salvarani, Maria Antonietta D’Agostino, Florenzo Iannone, Marco Matucci-Cerinic, Clodoveo Ferri, Silvia Bellando Randone
Format:	Artigo
Idioma:	Inglês
Publicat:	SAGE Publishing 2026-02-01
Col·lecció:	Therapeutic Advances in Musculoskeletal Disease
Accés en línia:	https://doi.org/10.1177/1759720X251410243
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