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Th7R predicts chemo-immunotherapy response and survival in small cell lung cancer

Abstract Th7R is a novel Th1-like CD4+ T cell lineage characterized by TCF7 and IL-7 receptor expression, exhibiting distinct transcriptional and epigenetic profiles compared with classical Th1 cells. The clinical significance of Th7R, including the efficacy of immune checkpoint inhibitors and the p...

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Principais autores: Shota Takei, Ayako Shiono, Satoshi Yamasaki, Ou Yamaguchi, Atsuto Mouri, Yu Miura, Kosuke Hashimoto, Hisao Imai, Kyoichi Kaira, Hiroshi Kagamu
Formato: Artigo
Idioma:Inglês
Publicado em: Springer 2025-12-01
coleção:Cancer Immunology, Immunotherapy
Assuntos:
Th7R
CD4+ T cell
Small cell lung cancer
Immune checkpoint blockade
Precursor exhausted T cells (Tpex)
Tumor microenvironment
Acesso em linha:https://doi.org/10.1007/s00262-025-04242-6
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