Th7R predicts chemo-immunotherapy response and survival in small cell lung cancer

Abstract Th7R is a novel Th1-like CD4+ T cell lineage characterized by TCF7 and IL-7 receptor expression, exhibiting distinct transcriptional and epigenetic profiles compared with classical Th1 cells. The clinical significance of Th7R, including the efficacy of immune checkpoint inhibitors and the p...

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Bibliografiske detaljer

Principais autores:	Shota Takei, Ayako Shiono, Satoshi Yamasaki, Ou Yamaguchi, Atsuto Mouri, Yu Miura, Kosuke Hashimoto, Hisao Imai, Kyoichi Kaira, Hiroshi Kagamu
Format:	Artigo
Sprog:	Inglês
Udgivet:	Springer 2025-12-01
Serier:	Cancer Immunology, Immunotherapy
Fag:	Th7R CD4+ T cell Small cell lung cancer Immune checkpoint blockade Precursor exhausted T cells (Tpex) Tumor microenvironment
Online adgang:	https://doi.org/10.1007/s00262-025-04242-6
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