Role of p16INK4A in Replicative Senescence and DNA Damage-Induced Premature Senescence in p53-Deficient Human Cells
The p16INK4A (hereafter p16) tumor suppressor is encoded by the INK4A/ARF locus which is among the most commonly dysregulated sequences in human cancer. By inhibiting cyclin-dependent kinases, p16 activates the G1-S checkpoint, and this response is often considered to be critical for establishing a...
Guardat en:
| Autors principals: | , , , |
|---|---|
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Wiley
2012-01-01
|
| Col·lecció: | Biochemistry Research International |
| Accés en línia: | http://dx.doi.org/10.1155/2012/951574 |
| Etiquetes: |
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|