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Interaction between <i>M. tuberculosis</i> Lineage and Human Genetic Variants Reveals Novel Pathway Associations with Severity of TB

Tuberculosis (TB) remains a major public health threat globally, especially in sub-Saharan Africa. Both human and <i>Mycobacterium tuberculosis</i> (MTBC) genetic variation affect TB outcomes, but few studies have examined if and how the two genomes interact to affect disease. We hypothesize that lo...

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Principais autores: Michael L. McHenry, Eddie M. Wampande, Moses L. Joloba, LaShaunda L. Malone, Harriet Mayanja-Kizza, William S. Bush, W. Henry Boom, Scott M. Williams, Catherine M. Stein
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-11-01
Serier:Pathogens
Fag:
tuberculosis severity
<i>M. tuberculosis</i>
population genetics
lineage-based GWAS
<i>M. tuberculosis</i>–human coevolution
Online adgang:https://www.mdpi.com/2076-0817/10/11/1487
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