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Vaccinia Virus Ankyrin-Repeat/F-Box Protein Targets Interferon-Induced IFITs for Proteasomal Degradation

Summary: IFITs are interferon-induced proteins that can bind 5′-triphosphate or ribose-unmethylated capped ends of mRNA to inhibit translation. Although some viruses avoid IFITs by synthesizing RNAs with eukaryotic-like caps, no viral proteins were known to antagonize IFITs. We show that the N- and...

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Hlavní autoři: Ruikang Liu, Lisa R. Olano, Yeva Mirzakhanyan, Paul D. Gershon, Bernard Moss
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019-10-01
Edice:Cell Reports
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2211124719312276
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