BRCA1/2 alterations and reversion mutations in the area of PARP inhibitors in high grade ovarian cancer: state of the art and forthcoming challenges

BRCA1/2 genes are part of homologous recombination (HR) DNA repair pathways in charge of error-free double-strand break (DSB) repair. Loss-of-function mutations of BRCA1/2 genes have been associated for a long time with breast and ovarian cancer hereditary syndrome. Recently, polyadenosine diphospha...

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Principais autores:	Laetitia Collet, Brunhilde Hanvic, Margherita Turinetto, Isabelle Treilleux, Nicolas Chopin, Olivia Le Saux, Isabelle Ray-Coquard
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2024-03-01
coleção:	Frontiers in Oncology
Assuntos:	high grade ovarian cancer BRCA1/2 mutation reversion mutation PARP inhibitor resistance homologous recombination deficiency
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1354427/full
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