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BRCA1/2 alterations and reversion mutations in the area of PARP inhibitors in high grade ovarian cancer: state of the art and forthcoming challenges

BRCA1/2 genes are part of homologous recombination (HR) DNA repair pathways in charge of error-free double-strand break (DSB) repair. Loss-of-function mutations of BRCA1/2 genes have been associated for a long time with breast and ovarian cancer hereditary syndrome. Recently, polyadenosine diphospha...

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Principais autores: Laetitia Collet, Brunhilde Hanvic, Margherita Turinetto, Isabelle Treilleux, Nicolas Chopin, Olivia Le Saux, Isabelle Ray-Coquard
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-03-01
Serier:Frontiers in Oncology
Fag:
high grade ovarian cancer
BRCA1/2 mutation
reversion mutation
PARP inhibitor
resistance
homologous recombination deficiency
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2024.1354427/full
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