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Dying for change: A roadmap to refine the fish acute toxicity test after 40 years of applying a lethal endpoint

The fish acute toxicity test (TG203; OECD, 2019) is frequently used and highly embedded in hazard and risk assessment globally. The test estimates the concentration of a chemical that kills 50% of the fish (LC50) over a 96 h exposure and is considered one of the most severe scientific procedures und...

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Uloženo v:
Hlavní autoři: Ioanna Katsiadaki, Tim Ellis, Linda Andersen, Philipp Antczak, Ellen Blaker, Natalie Burden, Tom Fisher, Christopher Green, Briony Labram, Audrey Pearson, Karina Petersen, Dan Pickford, Chris Ramsden, Anita Rønneseth, Kathy Ryder, Dominic Sacker, Chloe Stevens, Haruna Watanabe, Hiroshi Yamamoto, Fiona Sewell, Penny Hawkins, Hans Rufli, Richard D. Handy, Samuel K. Maynard, Miriam N. Jacobs
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021-10-01
Edice:Ecotoxicology and Environmental Safety
Témata:
TG203
Refinement
Regulatory toxicology
Humane endpoints
On-line přístup:http://www.sciencedirect.com/science/article/pii/S0147651321006977
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