Syntheses and Cell-Based Phenotypic Screen of Novel 7-Amino pyrido[2,3-d]pyrimidine-6-carbonitrile Derivatives as Potential Antiproliferative Agents

A series of N-3-substituted 7-aminopyrido[2,3-d]pyrimidin-6-carbonitrile derivatives was readily synthesized and their anti-proliferative activities on five types of tumor cells were evaluated through a cell-based phenotypic screening approach. Compound 3k was found to be potent on human colon cance...

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Bibliografiske detaljer

Principais autores:	Yan-Ni Lin, Hua-Cheng Yang, Wei-Yi Pi, Zi-Cheng Li, Ying-Lan Zhao, You-Fu Luo, Yuquan Wei, Ying-Hong Yang, Jian-Zhong Yang, Hong He, Wei Ang, Tao Yang
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI AG 2012-02-01
Serier:	Molecules
Fag:	7-aminopyrido[2,3-d]pyrimidin-6-carbonitrile derivatives cell-based phenotypic screening anti-tumor activity structure-activity relationship (SAR) apoptosis
Online adgang:	http://www.mdpi.com/1420-3049/17/3/2351/
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