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Synthesis and anticancer evaluation of diaryl pyrido[2,3-d]pyrimidine /alkyl substituted pyrido[2,3-d]pyrimidine derivatives as thymidylate synthase inhibitors

Abstract Worldwide, colorectal cancer (CRC) is the third most common type of cancer and the second most common cause of cancer-related deaths. Thymidylate synthase (TS) is a crucial component of DNA biosynthesis and has drawn interest as an essential target for cancer treatment. In the current work,...

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Principais autores: Adarsh Kumar, Nabeel Backer, Harshali Paliwal, Ankit Kumar Singh, Tanushree Debbaraman, Vikramjeet Singh, Pradeep Kumar
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-08-01
coleção:BMC Chemistry
Assuntos:
Colorectal cancer
Pyrido[2,3-d]pyrimidine
Thymidylate synthase
Anticancer
In silico studies
Acesso em linha:https://doi.org/10.1186/s13065-024-01228-w
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