Upper respiratory tract immunization with Pam2Cys-adjuvanted spike protein vaccine achieves sterilizing protection against SARS-CoV-2

Injected COVID-19 vaccines protect against severe disease, but do not induce robust mucosal immune responses. Nasal vaccines offer the advantage of local immunity to block viral infection and transmission. Previously we showed immunization of a Pam2Cys-adjuvanted SARS-CoV-2 vaccine to the upper and...

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Principais autores:	Erica L. Stewart, Skye Stockdale, Matt D. Johansen, Lachlan Smith, Sibel Alca, Joshua W. C. Maxwell, Duc H. Nguyen, Stefan Miemczyk, Guanshu Zhao, Stuart Turville, James A. Triccas, Megan Steain, Scott N. Byrne, Philip M. Hansbro, Richard J. Payne, Warwick J. Britton, Anneliese S. Ashhurst
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-09-01
coleção:	Frontiers in Immunology
Assuntos:	nasal vaccines mucosal immunity subunit vaccination mucosal adjuvant COVID-19 SARS-CoV-2
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1654126/full
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