Upper respiratory tract immunization with Pam2Cys-adjuvanted spike protein vaccine achieves sterilizing protection against SARS-CoV-2

Injected COVID-19 vaccines protect against severe disease, but do not induce robust mucosal immune responses. Nasal vaccines offer the advantage of local immunity to block viral infection and transmission. Previously we showed immunization of a Pam2Cys-adjuvanted SARS-CoV-2 vaccine to the upper and...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Erica L. Stewart, Skye Stockdale, Matt D. Johansen, Lachlan Smith, Sibel Alca, Joshua W. C. Maxwell, Duc H. Nguyen, Stefan Miemczyk, Guanshu Zhao, Stuart Turville, James A. Triccas, Megan Steain, Scott N. Byrne, Philip M. Hansbro, Richard J. Payne, Warwick J. Britton, Anneliese S. Ashhurst
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2025-09-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	nasal vaccines mucosal immunity subunit vaccination mucosal adjuvant COVID-19 SARS-CoV-2
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1654126/full
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!