De novo-designed transmembrane domains tune engineered receptor functions

De novo-designed receptor transmembrane domains (TMDs) present opportunities for precise control of cellular receptor functions. We developed a de novo design strategy for generating programmed membrane proteins (proMPs): single-pass α-helical TMDs that self-assemble through computationally defined...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Assaf Elazar, Nicholas J Chandler, Ashleigh S Davey, Jonathan Y Weinstein, Julie V Nguyen, Raphael Trenker, Ryan S Cross, Misty R Jenkins, Melissa J Call, Matthew E Call, Sarel J Fleishman
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	eLife Sciences Publications Ltd 2022-05-01
Цуврал:	eLife
Нөхцлүүд:	de novo design membrane protein transmembrane chimeric antigen receptor CAR T cell immunotherapy
Онлайн хандалт:	https://elifesciences.org/articles/75660
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