Protective effects of intrathecal injection of AAV9-RabGGTB-GFP+ in SOD1G93A mice

IntroductionAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that widely affects motor neurons of the CNS. About 20% of patients with ALS have familial ALS (fALS). One of the classic models of ALS are SOD1G93A mice. Misfolded SOD1 protein can be overexpressed in motor neurons, whic...

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Prif Awduron:	Tianchu Gao, Jia Huo, Cheng Xin, Jing Yang, Qi Liu, Hui Dong, Rui Li, Yaling Liu
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2023-03-01
Cyfres:	Frontiers in Aging Neuroscience
Pynciau:	amyotrophic lateral sclerosis SOD1G93A intrathecal injection of AAV motoneuron RabGGTB SOD1 aggregation
Mynediad Ar-lein:	https://www.frontiersin.org/articles/10.3389/fnagi.2023.1092607/full
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