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Exosome-enabled bone defect repair: mechanistic foundations, bioengineered delivery, and artificial intelligence-driven translation

Abstract Bone defects remain a substantial clinical burden. Exosomes have been extensively investigated as cell-free therapeutic candidates, exhibiting favorable biocompatibility and potential applicability in bone defect repair. Mechanisms relevant to bone regeneration are delineated, including act...

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Main Authors: Shen Yang, Siliang Ge, Zhongyang Liu, Junyu Chen, Feifan Chang, Junmin Shen, Fanfeng Wu, Xinyu Sun, Zhongqi Wang, Yi Li, Mingming Zhang, Ruijing Chen, Taojin Feng, Tao Yin, Pincong Fu, Ming Chen, Pengbin Yin, Libo Hao
Format: Artigo
Language:Inglês
Published: BMC 2026-03-01
Series:Journal of Nanobiotechnology
Subjects:
Exosomes
Bone defect repair
Bioengineered delivery systems
Biomaterials
Artificial intelligence
Translational medicine
Online Access:https://doi.org/10.1186/s12951-026-04176-w
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