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High transconjugation efficiency of fusion plasmid pNDM_KPC in carbapenem-resistant Citrobacter freundii and its formation driven by IS26-mediated integration

ABSTRACT Carbapenem-resistant Enterobacteriales (CRE) are increasingly recognized as reemerging nosocomial pathogens due to the dissemination of dual carbapenemase production. This study investigates the coexistence of blaKPC-2 and blaNDM-1 in CRE isolates, harbored on plasmids either separately and...

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Principais autores: Yuxiaoting Li, Xinhong Han, Xiangping Shi, Caiping Mao, Ting Yu, Yufeng Zhu, Shengjun Wu, Youping Huang, Yunsong Yu, Ying Fu
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2025-10-01
Series:Microbiology Spectrum
Assuntos:
Carbapenem-resistant
Citrobacter freundii
pNDM_KPC
NDM-1
KPC-2
IS26
Acceso en liña:https://journals.asm.org/doi/10.1128/spectrum.00905-25
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