The MMTV-Wnt1 murine model produces two phenotypically distinct subtypes of mammary tumors with unique therapeutic responses to an EGFR inhibitor

The Wnt gene family encodes an evolutionarily conserved group of proteins that regulate cell growth, differentiation and stem cell self-renewal. Aberrant Wnt signaling in human breast tumors has been proposed as a driver of tumorigenesis, especially in the basal-like tumor subtype where canonical Wn...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Adam D. Pfefferle, David B. Darr, Benjamin C. Calhoun, Kevin R. Mott, Jeffrey M. Rosen, Charles M. Perou
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	The Company of Biologists 2019-07-01
Edice:	Disease Models & Mechanisms
Témata:	Breast cancer MMTV-Wnt1 Genetically engineered mouse model EGFR inhibitor
On-line přístup:	http://dmm.biologists.org/content/12/7/dmm037192
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!