Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G<sub>1 </sub>cell cycle arrest and autophagy
<p>Abstract</p> <p>Background</p> <p>Selective cyclooxygenase (COX)-2 inhibitors elicit anti-proliferative responses in various tumours, however the underlying anti-tumour mechanisms are unclear. Mutational inactivation of the tumour suppressor p53 gene is frequent in malignant gliomas. The role of...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2009-08-01
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| coleção: | Molecular Cancer |
| Acesso em linha: | http://www.molecular-cancer.com/content/8/1/66 |
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