Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G₁cell cycle arrest and autophagy

<p>Abstract</p> <p>Background</p> <p>Selective cyclooxygenase (COX)-2 inhibitors elicit anti-proliferative responses in various tumours, however the underlying anti-tumour mechanisms are unclear. Mutational inactivation of the tumour suppressor p53 gene is frequent in malignant gliomas. The role of...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Gao Qiuhan, Yong Sook, Zhu Congju, Kang Khong, Wong Meng
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BMC 2009-08-01
Sarja:	Molecular Cancer
Linkit:	http://www.molecular-cancer.com/content/8/1/66
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