Discovery of Two Inhibitors of the Type IV Pilus Assembly ATPase PilB as Potential Antivirulence Compounds

ABSTRACT With the pressing antibiotic resistance pandemic, antivirulence has been increasingly explored as an alternative strategy against bacterial infections. The bacterial type IV pilus (T4P) is a well-documented virulence factor and an attractive target for small molecules for antivirulence purp...

Descripció completa

Dades bibliogràfiques

Autors principals:	Keane J. Dye, Nancy J. Vogelaar, Megan O’Hara, Pablo Sobrado, Webster Santos, Paul R. Carlier, Zhaomin Yang
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology 2022-12-01
Col·lecció:	Microbiology Spectrum
Matèries:	antivirulence PilB ATPase type IV pilus T4P assembly high-throughput screen benserazide
Accés en línia:	https://journals.asm.org/doi/10.1128/spectrum.03877-22
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!