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Highly Efficient, Rapid and Co-CRISPR-Independent Genome Editing in Caenorhabditis elegans

We describe a rapid and highly efficient method to generate point mutations in Caenorhabditis elegans using direct injection of CRISPR-Cas9 ribonucleoproteins. This versatile method does not require sensitized genetic backgrounds or co-CRISPR selection-based methods, and represents a single strategy...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Harriet Prior, Ali K. Jawad, Lauren MacConnachie, Asim A. Beg
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017-11-01
Schriftenreihe:G3: Genes, Genomes, Genetics
Schlagworte:
CRISPR
Cas9
ribonucleoprotein
Caenorhabditis elegans
disease variants
Online-Zugang:http://g3journal.org/lookup/doi/10.1534/g3.117.300216
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