Biochemical and epigenomic dissection of TFIIE function reveals gene-selective requirement in human transcription

Abstract The general transcription factor TFIIE is believed to be universally required for RNA polymerase II (Pol II)-mediated transcription initiation. However, our biochemical assays and ENCODE ChIP-seq data suggest a more gene-selective role. Using Mediator-depleted HeLa nuclear extracts, we show...

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Egile Nagusiak:	Murat A. Cevher, Pasindu N. Wijerathne, Yasemin Yozgat, Sevda Cevher, Keiichi Ito, Ali Cihan, Gulnara Zaynullina, ShiQi Pan, Serena Karlic
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Nature Portfolio 2026-01-01
Saila:	Scientific Reports
Sarrera elektronikoa:	https://doi.org/10.1038/s41598-026-36090-4
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