Biochemical and epigenomic dissection of TFIIE function reveals gene-selective requirement in human transcription
Abstract The general transcription factor TFIIE is believed to be universally required for RNA polymerase II (Pol II)-mediated transcription initiation. However, our biochemical assays and ENCODE ChIP-seq data suggest a more gene-selective role. Using Mediator-depleted HeLa nuclear extracts, we show...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2026-01-01
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| Serie: | Scientific Reports |
| Accesso online: | https://doi.org/10.1038/s41598-026-36090-4 |
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