Molecular characterisation of the trafficking rescue of defective ABCB4 variants by roscovitine analogues

Abstract ABCB4 is expressed at the canalicular membrane of hepatocytes and is responsible for the secretion of phosphatidylcholine into bile. Genetic variations of ABCB4 are associated with rare cholestatic liver diseases, the most severe being progressive familial intrahepatic cholestasis type 3, f...

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Autori principali:	Manon Banet, Veronica Crespi, Jonathan Elie, Yosra Riahi, Mounia Lakli, Elodie Mareux, Emmanuel Gonzales, Emmanuel Jacquemin, Laurent Meijer, Martine Lapalus, Florent Di Meo, Thomas Falguières
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-02-01
Serie:	Scientific Reports
Soggetti:	ABC transporters Bile secretion Targeted pharmacotherapy Drug candidates Molecular modelling
Accesso online:	https://doi.org/10.1038/s41598-026-39840-6
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