Molecular characterisation of the trafficking rescue of defective ABCB4 variants by roscovitine analogues

Abstract ABCB4 is expressed at the canalicular membrane of hepatocytes and is responsible for the secretion of phosphatidylcholine into bile. Genetic variations of ABCB4 are associated with rare cholestatic liver diseases, the most severe being progressive familial intrahepatic cholestasis type 3, f...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Manon Banet, Veronica Crespi, Jonathan Elie, Yosra Riahi, Mounia Lakli, Elodie Mareux, Emmanuel Gonzales, Emmanuel Jacquemin, Laurent Meijer, Martine Lapalus, Florent Di Meo, Thomas Falguières
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Nature Portfolio 2026-02-01
سلاسل:	Scientific Reports
الموضوعات:	ABC transporters Bile secretion Targeted pharmacotherapy Drug candidates Molecular modelling
الوصول للمادة أونلاين:	https://doi.org/10.1038/s41598-026-39840-6
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!