Lipid-induced S-palmitoylation of Insulin-Responsive Aminopeptidase (IRAP) drives the onset of insulin resistance in the heart

Abstract Excessive accumulation of long-chain fatty acids (LCFAs) in cardiomyocytes leads to cardiac lipid-induced insulin resistance (CLIR), impairing insulin signaling and glucose uptake. This metabolic disruption marks a prediabetic state in which cardiomyocytes rely predominantly on lipids for e...

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Prif Awduron:	Francesco Schianchi, Jeroen Guns, Freek G. Bouwman, Jeroen F.J. Bogie, Miranda Nabben, Agnieszka Strzelecka, Rick van Leeuwen, Dimitris Kapsokalyvas, Kaitlyn M.J.H. Dennis, Lisa C. Heather, Shujin Wang, Jan F.C. Glatz, Dietbert Neumann, Joost J.F.P. Luiken
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Springer 2026-03-01
Cyfres:	Cellular and Molecular Life Sciences
Pynciau:	Cardiac lipid-induced insulin resistance S-palmitoylation DHHC Insulin-stimulated glucose uptake IRAP
Mynediad Ar-lein:	https://doi.org/10.1007/s00018-026-06179-0
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