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Structural Insights Into TDP-43 and Effects of Post-translational Modifications

Transactive response DNA binding protein (TDP-43) is a key player in neurodegenerative diseases. In this review, we have gathered and presented structural information on the different regions of TDP-43 with high resolution structures available. A thorough understanding of TDP-43 structure, effect of...

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Principais autores: Liberty François-Moutal, Samantha Perez-Miller, David D. Scott, Victor G. Miranda, Niloufar Mollasalehi, May Khanna
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-12-01
coleção:Frontiers in Molecular Neuroscience
Assuntos:
TDP-43 = TAR DNA–binding protein 43
structure
post-translational modification
subdomains
RRM domain
Acesso em linha:https://www.frontiersin.org/article/10.3389/fnmol.2019.00301/full
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