Surface downmodulation of TIM3 safeguards healthy cells but not acute myeloid leukemia from CAR T‐cell therapy

Abstract T‐cell immunoglobulin and mucin‐domain containing‐3 (TIM3), generally known as an immune checkpoint receptor, is expressed on leukemic stem and progenitor cells (LSPCs) in acute myeloid leukemia (AML), and has an active role in LSC self‐renewal. Therefore, TIM3 has been suggested as a poten...

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Autores principales:	Jort J. van derSchans, Paresh Vishwasrao, Renée Poels, Morgan Antti, Ziyu Wang, Marjolein Quik, Jennemiek vanArkel, Tom Reuvekamp, Niels W. C. J. van deDonk, Maria Themeli, Gert J. Ossenkoppele, Arjan A. van deLoosdrecht, Rebecca Richards, Tuna Mutis
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Wiley 2025-07-01
Colección:	HemaSphere
Acceso en línea:	https://doi.org/10.1002/hem3.70155
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