Emerging strategies in CAR-T cell therapy for acute myeloid leukemia: overcoming heterogeneity and improving safety through dual-antigen targeting

Abstract While CAR-T cell therapy has been very successful for treating B cell malignancies, and more recently multiple myeloma, achieving clinical success for acute myeloid leukemia (AML) remains a significant challenge. The examination of current single-antigen targeting CAR-T cell studies for AML...

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Detalhes bibliográficos

Principais autores:	Ángeles Ocaña-Cara, Tuna Mutis, Jort J. van der Schans
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-11-01
coleção:	Experimental Hematology & Oncology
Assuntos:	Acute myeloid leukemia Chimeric antigen receptor T cell Immunotherapy Antigen expression Dual-antigen targeting
Acesso em linha:	https://doi.org/10.1186/s40164-025-00726-4
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