Parthanatos drives cognitive decline in repeated brain trauma: MSC-derived exosomes as a novel therapeutic strategy

IntroductionRepetitive traumatic brain injury (RTBI) represents a cumulative neurological insult associated with progressive neurodegeneration and limited therapeutic options. In this study, we uniquely evaluate the neuroprotective potential of mesenchymal stem cell (MSC)-derived exosomes in a rat m...

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Bibliografiske detaljer

Principais autores:	Heba Mohammed Refat M. Selim, Amira A. El-Gazar, Dalaal M. Abdallah, Hagar B. Abo-Zalam, Ghada M. Ragab, Ahmed N. Abdallah, Rabab A. El-Gazar, Sultan Alshehri, Einas M. Yousef, Rayan Ballal, Sahar N. Aljarallah, Asmaa Saleh, Nada F. Abou Chahin, Naheda S. Alsammak, Rasha A. Mandil, Hanan S. El-Abhar
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2025-09-01
Serier:	Frontiers in Pharmacology
Fag:	exosomes parthanatos cyclophilin B PARP1 calpain oxidative stress
Online adgang:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1622018/full
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