p53 status determines the epigenetic response to demethylating agents azacitidine and decitabine
Abstract 5’-Azacitidine (Aza) and 5-Aza-2’-deoxycytidine (Dac) are widely used demethylating drugs that directly integrate into nucleic acids. They are frequently used interchangeably, surprisingly as their selectivity is unique from the other, with no predictors of response or clinical biomarkers t...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer Nature
2026-01-01
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| Schriftenreihe: | EMBO Reports |
| Schlagworte: | |
| Online-Zugang: | https://doi.org/10.1038/s44319-025-00678-0 |
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