A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis).
<h4>Background</h4>During severe (pneumo)sepsis inflammatory and coagulation pathways become activated as part of the host immune response. Thrombomodulin (TM) is involved in a range of host defense mechanisms during infection and plays a pivotal role in activation of protein C (PC) into active prot...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science (PLoS)
2014-04-01
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| シリーズ: | PLoS Neglected Tropical Diseases |
| オンライン･アクセス: | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002819&type=printable |
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