A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis).

<h4>Background</h4>During severe (pneumo)sepsis inflammatory and coagulation pathways become activated as part of the host immune response. Thrombomodulin (TM) is involved in a range of host defense mechanisms during infection and plays a pivotal role in activation of protein C (PC) into active prot...

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Autors principals:	Liesbeth M Kager, W Joost Wiersinga, Joris J T H Roelofs, Onno J de Boer, Hartmut Weiler, Cornelis van 't Veer, Tom van der Poll
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2014-04-01
Col·lecció:	PLoS Neglected Tropical Diseases
Accés en línia:	https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002819&type=printable
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