Pathological MAPK activation–mediated lymphatic basement membrane disruption causes lymphangiectasia that is treatable with ravoxertinib

Lymphangiectasia, an anomalous dilation of lymphatic vessels first described in the 17th century, is frequently associated with chylous effusion, respiratory failure, and high mortality in young patients, yet the underlying molecular pathogenesis and effective treatments remain elusive. Here, we ide...

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Autores principales:	Harish P. Janardhan, Karen Dresser, Lloyd Hutchinson, Chinmay M. Trivedi
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical investigation 2022-09-01
Colección:	JCI Insight
Materias:	Development Vascular biology
Acceso en línea:	https://doi.org/10.1172/jci.insight.153033
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