Influence of UGT1A1 polymorphisms on the outcome of acute myeloid leukemia patients treated with cytarabine-base regimens

Abstract Backgrounds UDP-glucuronosyltransferase 1A subfamily (UGT1A) enzymes can inactivate cytarabine (Ara-C) by glucuronidation, and thus serves as candidate genes for interindividual difference in Ara-C response. UGT1A1 is a major UGT1A isoform expressed in human liver. Methods UGT1A1*6 and *28...

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Hauptverfasser:	Peng Chen, Ke-Wei Zhu, Dao-Yu Zhang, Han Yan, Han Liu, Yan-Ling Liu, Shan Cao, Gan Zhou, Hui Zeng, Shu-Ping Chen, Xie-Lan Zhao, Jing Yang, Xiao-Ping Chen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2018-07-01
Schriftenreihe:	Journal of Translational Medicine
Schlagworte:	Cytarabine (Ara-C) Acute myeloid leukemia (AML) UDP-glucuronosyltransferase family 1 member A1 (UGT1A1) Polymorphism
Online-Zugang:	http://link.springer.com/article/10.1186/s12967-018-1579-3
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