Structure of human DNA polymerase kappa inserting dATP opposite an 8-OxoG DNA lesion.

<h4>Background</h4>Oxygen-free radicals formed during normal aerobic cellular metabolism attack bases in DNA and 7,8-dihydro-8-oxoguanine (8-oxoG) is one of the major lesions formed. It is amongst the most mutagenic lesions in cells because of its dual coding potential, wherein 8-oxoG(syn) can pair...

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Hlavní autoři:	Rodrigo Vasquez-Del Carpio, Timothy D Silverstein, Samer Lone, Michael K Swan, Jayati R Choudhury, Robert E Johnson, Satya Prakash, Louise Prakash, Aneel K Aggarwal
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2009-06-01
Edice:	PLoS ONE
On-line přístup:	https://doi.org/10.1371/journal.pone.0005766
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