The Role of Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis

The Hedgehog (Hh)-glioma-associated oncogene homolog (GLI) signaling pathway is highly conserved among mammals, with crucial roles in regulating embryonic development as well as in cancer initiation and progression. The GLI transcription factors (GLI1, GLI2, and GLI3) are effectors of the Hh pathway...

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Principais autores:	Jian Yi Chai, Vaisnevee Sugumar, Mohammed Abdullah Alshawsh, Won Fen Wong, Aditya Arya, Pei Pei Chong, Chung Yeng Looi
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2021-09-01
Serija:	Biomedicines
Teme:	GLI1 protein hedgehog pathway mutations epigenetic regulation glioma-associated oncogene noncanonical
Online dostop:	https://www.mdpi.com/2227-9059/9/9/1188
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