Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma

Transcriptional dysregulation of genes is a hallmark of tumors and can serve as targets for cancer drug development. However, it is extremely challenging to develop small-molecule inhibitors to target abnormally expressed transcription factors (TFs) except for the nuclear receptor family of TFs. Lit...

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Autors principals:	Li Peng, Yanyi Jiang, Hengxing Chen, Yongqiang Wang, Qiusheng Lan, Shuiqin Chen, Zhanwang Huang, Jingyuan Zhang, Duanqing Tian, Yuntan Qiu, Diankui Cai, Jiangyun Peng, Daning Lu, Xiaoqing Yuan, Xianzhu Yang, Dong Yin
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-05-01
Col·lecció:	Acta Pharmaceutica Sinica B
Matèries:	EHF AJUBA KRAS pathway Enhancer Core transcriptional regulatory circuitry Gastroesophageal adenocarcinoma
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211383524000789
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