Correlation of MGMT promoter methylation status with gene and protein expression levels in glioblastoma

OBJECTIVES: 1) To correlate the methylation status of the O6-methylguanine-DNA-methyltransferase (MGMT) promoter to its gene and protein expression levels in glioblastoma and 2) to determine the most reliable method for using MGMT to predict the response to adjuvant therapy in patients with glioblas...

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Autori principali:	Miyuki Uno, Sueli Mieko Oba-Shinjo, Anamaria Aranha Camargo, Ricardo Pereira Moura, Paulo Henrique de Aguiar, Hector Navarro Cabrera, Marcos Begnami, Sérgio Rosemberg, Manoel Jacobsen Teixeira, Suely Kazue Nagahashi Marie
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier España 2011-01-01
Serie:	Clinics
Soggetti:	Glioblastoma; MGMT promoter methylation MGMT gene MGMT protein Prognosis
Accesso online:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011001000013
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