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Correlation of MGMT promoter methylation status with gene and protein expression levels in glioblastoma

OBJECTIVES: 1) To correlate the methylation status of the O6-methylguanine-DNA-methyltransferase (MGMT) promoter to its gene and protein expression levels in glioblastoma and 2) to determine the most reliable method for using MGMT to predict the response to adjuvant therapy in patients with glioblas...

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Principais autores: Miyuki Uno, Sueli Mieko Oba-Shinjo, Anamaria Aranha Camargo, Ricardo Pereira Moura, Paulo Henrique de Aguiar, Hector Navarro Cabrera, Marcos Begnami, Sérgio Rosemberg, Manoel Jacobsen Teixeira, Suely Kazue Nagahashi Marie
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier España 2011-01-01
Serier:Clinics
Fag:
Glioblastoma; MGMT promoter methylation
MGMT gene
MGMT protein
Prognosis
Online adgang:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011001000013
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