Itraconazole (ITRA) with Standard Radiotherapy (RT) and Temozolomide (TMZ) in Patients with Newly Diagnosed Glioblastoma Multiforme (GBM) ITRA-RAD: Phase I Clinical Study
Preclinical studies and data from other cancers suggest that inhibition of the Hedgehog (Hh) pathway also has antiproliferative effects on glioma cells. A key component of this pathway is the Smoothened (SMO) protein, which is expressed in high-grade gliomas. Itraconazole (ITRA), a widely used antif...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
MDPI AG
2026-06-01
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| Col·lecció: | Radiation |
| Matèries: | |
| Accés en línia: | https://www.mdpi.com/2673-592X/6/2/19 |
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