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Co-administration of temozolomide (TMZ) and the experimental therapeutic targeting miR-10b, profoundly affects the tumorigenic phenotype of human glioblastoma cells

Introduction: Recent studies have shown that miRNA-10b is highly expressed in high-grade glioblastoma multiforme (GBM), and its inhibition leads to deregulation of multiple pathways in tumorigenesis, resulting in repression of tumor growth and increased apoptosis. Thus, we hypothesized that suppress...

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Principais autores: Ming Chen, Bryan Kim, Neil Robertson, Sujan Kumar Mondal, Zdravka Medarova, Anna Moore
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-06-01
Serier:Frontiers in Molecular Biosciences
Fag:
glioblastoma multiforme
microRNA
temozolomide
in vitro studies
nanoparticles
Online adgang:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1179343/full
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