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Pheno-SELEX: Engineering Anti-Metastatic Aptamers through Targeting the Invasive Phenotype Using Systemic Evolution of Ligands by Exponential Enrichment

Multiple methods (e.g., small molecules and antibodies) have been engineered to target specific proteins and signaling pathways in cancer. However, many mediators of the cancer phenotype are unknown and the ability to target these phenotypes would help mitigate cancer. Aptamers are small DNA or RNA...

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Principais autores: Greg Shelley, Jinlu Dai, Jill M. Keller, Evan T. Keller
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2021-12-01
Series:Bioengineering
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Acceso en liña:https://www.mdpi.com/2306-5354/8/12/212
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