CD2 targeted nanoparticles containing IL-2 mimic fetal-maternal tolerance of pregnancy by inducing synergistic TGF-β-producing NK cells and Tregs

T regulatory cells (Tregs) are essential for maintaining immune homeostasis and tolerance. We have reported that CD2-targeted nanoparticles containing IL-2 induce CD4 and CD8 Foxp3+ Tregs, together with TGF-β-producing CD56bright NK cells. Generation and maintenance of stable Tregs critically depend...

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Автори:	David A. Horwitz, Antonio La Cava
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Frontiers Media S.A. 2025-11-01
Серія:	Frontiers in Immunology
Предмети:	maternal-fetal tolerance T regulatory cells (Tregs) natural killer (NK) cells transforming growth factor β (TGF-β) nanoparticles
Онлайн доступ:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1692547/full
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