Spatially coordinated collective phosphorylation filters spatiotemporal noises for precise circadian timekeeping

Summary: The circadian (∼24h) clock is based on a negative-feedback loop centered around the PERIOD protein (PER), translated in the cytoplasm and then enters the nucleus to repress its own transcription at the right time of day. Such precise nucleus entry is mysterious because thousands of PER mole...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Seok Joo Chae, Dae Wook Kim, Seunggyu Lee, Jae Kyoung Kim
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2023-04-01
Schriftenreihe:	iScience
Schlagworte:	Physiology Cellular physiology Computer modeling
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2589004223006314
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